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Corneal biomechanical properties and their correlates with refractive error
Hema Radhakrishnan1, Marco A Miranda, Clare O'Donnell
1Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom. Hema.Radhakrishnan@manchester.ac.uk
Clinical & Experimental Optometry
|January 4, 2012
Summary
Mild to moderate myopia is associated with higher corneal resistance factor, but not corneal hysteresis. Refractive error explains only a small part of the variability in corneal biomechanical properties.
Area of Science:
- Ophthalmology
- Corneal Biomechanics
- Refractive Error
Background:
- Corneal biomechanical properties are crucial for ocular health.
- Understanding their relationship with refractive error is important for clinical practice.
Purpose of the Study:
- To investigate the association between refractive error and corneal biomechanical properties.
- To determine if corneal hysteresis (CH) and corneal resistance factor (CRF) correlate with refractive error.
Main Methods:
- Corneal hysteresis and corneal resistance factor were measured using the Ocular Response Analyser.
- 117 participants with refractive error ranging from -9.00 D to +3.00 D were included.
Main Results:
- Corneal hysteresis did not significantly correlate with refractive error (p = 0.82).
- Corneal resistance factor showed a weak but significant positive correlation with spherical equivalent refractive error (r(2) = 0.04; p = 0.03).
- Myopic participants exhibited a higher corneal resistance factor compared to non-myopes.
Conclusions:
- Refractive error accounts for 4% of the variance in corneal resistance factor.
- Mild to moderate myopia is associated with higher corneal resistance compared to non-myopic eyes.
- Corneal biomechanical properties show significant inter-individual variability.
