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Published on: September 16, 2025
Corneal biomechanical properties and their correlates with refractive error
Hema Radhakrishnan1, Marco A Miranda, Clare O'Donnell
1Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom. Hema.Radhakrishnan@manchester.ac.uk
Purpose:
The aim was to study the link between refractive error and corneal biomechanical properties.
Methods:
Corneal hysteresis and corneal resistance factor were measured using the Ocular Response Analyser in 117 participants. The spherical equivalent refractive error of the participants ranged between -9.00 and +3.00 D.
Results:
Corneal hysteresis and corneal resistance factor showed a considerable degree of variability between individuals. Corneal hysteresis was not found to correlate significantly with refractive error (p = 0.82). Corneal resistance factor showed a weak but significant correlation with spherical equivalent refractive error (r(2) = 0.04; p = 0.03), with myopic participants exhibiting a higher corneal resistance factor compared with non-myopes.
Conclusions:
Refractive error accounted for four per cent of the variance in corneal resistance factor measurements, indicating that patients with mild to moderate myopia have higher corneal resistance compared with non-myopes.
