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Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future

Ram N Ganapathi1, Ronald M Bukowski

  • 1Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. ganapar@ccf.org.

Genome Medicine
|January 4, 2012
PubMed

Insights

Single nucleotide polymorphisms (SNPs) in genes can impact the effectiveness and side effects of sunitinib, a targeted therapy for advanced clear cell renal cell carcinoma. Identifying these SNPs may help personalize treatment for better patient outcomes.

Area of Science:

  • Oncology
  • Pharmacogenomics

Background:

  • Targeted therapy, specifically tyrosine kinase inhibitors, has significantly improved treatment for advanced or metastatic clear cell renal cell carcinoma.
  • Understanding the genetic factors influencing drug response is crucial for optimizing cancer care.

Purpose of the Study:

  • To review single nucleotide polymorphisms (SNPs) associated with treatment outcomes and toxicity in patients receiving sunitinib.
  • To explore the potential of SNPs in developing personalized therapy strategies for clear cell renal cell carcinoma.

Main Methods:

  • Literature review of studies investigating SNPs related to sunitinib's mechanism of action, metabolism, and transport.
  • Analysis of the association between identified SNPs and clinical outcomes (efficacy and toxicity).

Main Results:

  • Certain single nucleotide polymorphisms (SNPs) are linked to variations in patient response and side effects to sunitinib therapy.
  • These genetic markers offer insights into individual drug metabolism and transport, influencing treatment efficacy.

Conclusions:

  • Single nucleotide polymorphisms (SNPs) play a role in sunitinib efficacy and toxicity for clear cell renal cell carcinoma.
  • Future clinical trials should incorporate SNP analysis to advance personalized medicine approaches in renal cell carcinoma treatment.

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