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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the cerebellum's...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
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Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

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Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

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Published on: April 23, 2014

[Schizophrenia, executive control and memory].

S-N Elissalde1, P Mazzola-Pomietto, N Viglianese

  • 1Pôle universitaire de psychiatrie, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13274 Marseille cedex 09, France. sara-nora.elissalde@ap-hm.fr

L'Encephale
|January 4, 2012
PubMed
Summary
This summary is machine-generated.

Schizophrenia is characterized by specific cognitive deficits, not global brain damage. Understanding these distinct cognitive impairments is key for personalized treatment and improved patient outcomes.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Context:

  • Schizophrenia impacts 1% of the population, presenting with both clinical and cognitive symptoms.
  • Cognitive deficits, rather than classical symptoms, may better define schizophrenia's diverse outcomes.
  • The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) recognizes cognition's importance, suggesting formal neuropsychological assessments.

Purpose:

  • To investigate the nature of cognitive deficits in schizophrenia.
  • To determine if cognitive impairments in schizophrenia are global or specific.
  • To explore the relationship between cognitive deficits, symptoms, and pre-morbid functioning.

Summary:

  • Studies show significant deficits in memory and executive control domains in schizophrenia patients.
  • However, not all memory systems are affected, invalidating the global damage hypothesis.
  • Cognitive deficits appear specific and influenced by dominant symptoms and pre-morbid functioning.

Impact:

  • Findings support the need for tailored cognitive assessment batteries for schizophrenia patients.
  • Highlights the potential for developing personalized cognitive remediation programs.
  • Emphasizes a shift towards understanding specific cognitive profiles for better patient management.