Blood-brain barrier permeability differentiates Sadowski mouse lines of high and low stress-induced analgesia:...

The blood-brain barrier (BBB) forms a filtering system between peripheral circulating blood and the central nervous system. Pathological leakage of the BBB is probably responsible for various dysfunctions and diseases. Over twenty years ago, Sadowski et al. separated two lines of mouse, one with high sensitivity (HA) and the other with low sensitivity (LA) to stress-induced analgesia (SIA). We propose that leakage of the BBB is responsible for the difference in SIA of the "Sadowski mouse" model. The presented BBB electron microscopy structural analysis of both lines provided evidence for this hypothesis. Up to now, a good natural animal model of differences of BBB permeability is not known. The "Sadowski mouse" may fulfil this deficiency.