Related Experiment Video
Updated: May 26, 2026

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
Published on: September 25, 2013
Signaling pathways in hepatocellular carcinoma.
Daniela Sia1, Augusto Villanueva
1HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Liver Unit, Hospital Clinic, Barcelona, Spain.
Hepatocellular carcinoma (HCC) is a deadly cancer linked to viral hepatitis. Molecular therapies like sorafenib offer hope for advanced cases by targeting cancer signaling pathways.
Area of Science:
- Hepatocellular carcinoma (HCC) research
- Oncology
- Molecular targeted therapy
Background:
- Hepatocellular carcinoma (HCC) ranks as the sixth most common cancer globally, with a high mortality rate.
- HCC incidence has risen due to viral hepatitis, leading to poor patient prognosis.
- Fewer than 30% of HCC patients are candidates for curative treatments.
Purpose of the Study:
- To investigate molecular therapies for advanced Hepatocellular carcinoma (HCC).
- To identify aberrant signaling pathways in HCC.
- To discover novel oncogenic addiction loops for developing targeted therapies.
Main Methods:
- Review of molecular therapies for Hepatocellular carcinoma (HCC).
- Analysis of signaling pathway activation in HCC.
- Exploration of targeted therapy development.
Main Results:
- Sorafenib, a tyrosine kinase inhibitor, has improved survival in advanced HCC patients.
- Targeted therapies show promise for Hepatocellular carcinoma (HCC) treatment.
- Identifying specific signaling pathway aberrations is key to effective treatment.
Conclusions:
- Molecular therapies represent a significant advancement in managing advanced Hepatocellular carcinoma (HCC).
- Further research into signaling pathways will uncover new therapeutic targets.
- Personalized medicine approaches hold promise for improving HCC outcomes.
More Related Videos
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
12:24A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Related Concept Videos
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Cirrhosis II: Pathophysiology
MAPK Signaling Cascades
mTOR Signaling and Cancer Progression
The mTOR pathway or the...