Related Experiment Videos
Halothane reductive metabolism in an adult surgical population
M A Jenner1, J L Plummer, M J Cousins
1Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Adelaide, South Australia.
Anaesthesia and Intensive Care
|August 1, 1990
Abstract:
The reductive metabolism of halothane was studied in 34 adult patients undergoing routine surgery. Reductive biotransformation of halothane was more extensive in females than males and was also enhanced in two patients treated preoperatively with phenytoin, an enzyme-inducing drug. Tobacco, ethanol and the patient's age, body weight and previous exposure to halothane did not influence reductive metabolism of halothane.