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Related Experiment Video

Updated: May 26, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Subthalamic neuronal responses to cortical stimulation.

Marcus L F Janssen1, Daphne G M Zwartjes, Yasin Temel

  • 1Department of Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands. m.janssen@maastrichtuniversity.nl

Movement Disorders : Official Journal of the Movement Disorder Society
|January 4, 2012
PubMed
Summary
This summary is machine-generated.

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Motor cortex stimulation helps identify specific subthalamic nucleus areas for Parkinson's disease deep brain stimulation. Lowering current density can prevent seizures, improving patient safety.

Area of Science:

  • Neuroscience
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) of the subthalamic nucleus (STN) effectively treats Parkinson's disease motor symptoms.
  • Cognitive and emotional side effects may arise from current spread to non-motor STN regions.

Purpose of the Study:

  • To identify the motor region of the STN using motor cortex stimulation (MCS).
  • To reduce stimulation-induced behavioral side effects in Parkinson's disease patients undergoing DBS.

Main Methods:

  • Subthalamic nucleus neuronal responses to hand area motor cortex stimulation were recorded.
  • The safety of this novel MCS technique was evaluated.

Main Results:

  • Distinct regional responses within the STN were observed.

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Related Experiment Videos

Last Updated: May 26, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Non-invasive Assessment of Changes in Corticomotoneuronal Transmission in Humans
09:30

Non-invasive Assessment of Changes in Corticomotoneuronal Transmission in Humans

Published on: May 24, 2017

  • Early excitation and subsequent inhibition were noted in anterior and lateral STN regions.
  • Focal seizures occurred following motor cortex stimulation.

    • Conclusions:

    • Motor cortex stimulation-evoked responses can be safely utilized during DBS surgery.
    • Reducing current density is crucial to prevent seizures and ensure patient safety.