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Updated: May 26, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

Nucleic acid functionalized graphene for biosensing.

Alessandra Bonanni1, Adriano Ambrosi, Martin Pumera

  • 1Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 4, 2012
PubMed
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Researchers developed a straightforward method to attach single-stranded DNA (ssDNA) to graphene, creating advanced graphene-based biosensors for sensitive DNA analysis and nanoelectronic applications.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Graphene nanostructures are crucial for advanced biosensing and nanoelectronics.
  • DNA offers versatile programmability for assembling nanomaterials.
  • Developing efficient DNA-graphene conjugation is key for novel devices.

Purpose of the Study:

  • To establish a facile covalent linking strategy for single-stranded DNA (ssDNA) onto graphene.
  • To investigate the efficacy of various chemically modified graphenes for ssDNA functionalization.
  • To develop graphene-based platforms for sensitive DNA hybridization and polymorphism detection.

Main Methods:

  • Utilized carbodiimide chemistry for covalent ssDNA-graphene linkage.
  • Prepared and characterized four distinct chemically modified graphene materials.

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A Polyaniline-based Sensor of Nucleic Acids
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A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

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Last Updated: May 26, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

  • Employed impedimetric methods for detecting DNA hybridization and polymorphism.

    • Main Results:

    • Successfully demonstrated covalent functionalization of graphene with ssDNA.
    • Evaluated the performance of different graphene modifications for DNA attachment.
    • Achieved sensitive detection of DNA hybridization and polymorphism using the functionalized platforms.

    Conclusions:

    • The developed strategy provides a robust method for creating DNA-functionalized graphene.
    • These platforms offer a promising alternative to traditional DNA analysis techniques.
    • Covalent ssDNA-graphene conjugation has wide-ranging applications in biosensing, nanoelectronics, and DNA-programmable self-assembly.