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Patterns and determinants of conjugated estrogen use
American Journal of Epidemiology
|June 1, 1979
Summary
Conjugated estrogens (CEs) were used by 13% of women aged 30-69. Use was linked to age, menopause, and symptoms, posing a public health concern due to potential endometrial cancer risks.
Area of Science:
- Endocrinology
- Public Health
- Oncology
Background:
- Conjugated estrogens (CEs) are widely used.
- Concerns exist regarding their carcinogenic potential, particularly for endometrial cancer.
Purpose of the Study:
- To evaluate patterns and determinants of oral ambulatory conjugated estrogen use.
- To assess the public health implications of CE use.
Main Methods:
- Survey of 1273 women aged 30-69 in Greater-Boston hospitals.
- Analysis of physician prescription survey data from an independent source.
Main Results:
- 13% of women were ever-users of CEs; 7% used them in the preceding year.
- Median duration of use was three years.
- Key determinants included age, menopause, and menopausal symptoms.
Conclusions:
- CE use, particularly in relation to endometrial cancer risk, presents a significant public health issue.
- CE use may have declined following 1975 reports linking them to endometrial cancer.