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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
Published on: November 26, 2010
Immunotherapy for metastatic colorectal cancer: present status and new options
Eva Ellebaek1, Mads Hald Andersen, Inge Marie Svane
1Department of Haematology, Center for Cancer Immune Therapy (CCIT), Copenhagen University Hospital Herlev, Herlev, Denmark. evaell02@heh.regionh.dk
Abstract:
Although no immunotherapeutic treatment is approved for colorectal cancer (CRC) patients, promising results from clinical trials suggest that several immunotherapeutic strategies may prove efficacious and applicable to this group of patients. This review describes the immunogenicity of CRC and presents the most interesting strategies investigated so far: cancer vaccination including antigen-defined vaccination and dendritic cell vaccination, chemo-immunotherapy, and adoptive cell transfer. Future treatment options as well as the possibility of combining existing therapies will be discussed along with the challenges presented by tumor escape mechanisms.
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