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What makes the engine hum: Rad6, a cell cycle supercharger

Jorrit M Enserink1, Richard D Kolodner

  • 1Department of Molecular Biology, Institute of Medical Microbiology and Centre of Molecular Biology and Neuroscience, Oslo University Hospital, Oslo, Norway. jorrit.enserink@rr-research.no

Cell Cycle (Georgetown, Tex.)
|January 5, 2012
PubMed

Insights

Researchers identified the Rad6-Bre1 pathway as crucial for cell cycle control in yeast. This pathway links ubiquitin levels to cyclin gene transcription, impacting cell viability and progression.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) are critical regulators of cell proliferation and are frequently deregulated in human cancers.
  • In yeast, Cdc28 is a key CDK controlling cell cycle progression, but its regulatory network is not fully understood.

Purpose of the Study:

  • To identify genes functioning with CDC28 to regulate cell cycle progression and viability in Saccharomyces cerevisiae.
  • To elucidate the genetic network of CDC28.

Main Methods:

  • A chemical-genetic screen was employed to identify genes interacting with CDC28.
  • Analysis focused on the functional connections within the identified genetic network.

Main Results:

  • The Rad6-Bre1 pathway was discovered to be part of the CDC28 genetic network.
  • This pathway connects ubiquitin levels to cell cycle progression.
  • Rad6-Bre1 enhances cyclin gene transcription, thereby boosting cell cycle machinery activity.

Conclusions:

  • The Rad6-Bre1 pathway plays a significant role in regulating cell cycle progression and viability in yeast.
  • Ubiquitin modification is a key mechanism linking gene expression to cell cycle control.

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