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Related Concept Videos

Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

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Updated: May 26, 2026

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
08:53

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo

Published on: January 10, 2025

Erythrocyte as a link between basic and clinical research.

C Saldanha1, J P Lopes de Almeida

  • 1University of Lisbon Medical School, Santa Maria Hospital, Lisbon, Portugal. carlotasaldanha@fm.ul.pt

Clinical Hemorheology and Microcirculation
|January 5, 2012
PubMed
Summary
This summary is machine-generated.

Erythrocyte aggregation, a key hemorheological factor, links basic science and clinical research. Studies suggest a connection between erythrocyte aggregation and plasma fibrinogen levels.

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Published on: August 5, 2011

Area of Science:

  • Hematology
  • Biophysics
  • Clinical Medicine

Background:

  • Erythrocyte aggregation is a significant hemorheological phenomenon.
  • Understanding erythrocyte aggregation is crucial for bridging basic science and clinical applications.

Purpose of the Study:

  • To review major hemorheological studies on erythrocyte aggregation.
  • To explore the link between erythrocyte aggregation and clinical research, particularly plasma fibrinogen.
  • To discuss in vitro studies elucidating factors influencing erythrocyte aggregation.

Main Methods:

  • Review of major hemorheological experimental studies.
  • Analysis of clinical cross-sectional and longitudinal study results.
  • Inclusion of in vitro basic studies.

Main Results:

  • Erythrocyte aggregation serves as a link between basic and clinical hemorheology.
  • Clinical studies indicate a potential association between erythrocyte aggregation and plasma fibrinogen.
  • In vitro studies provide insights into the mechanisms of erythrocyte aggregation and disaggregation.

Conclusions:

  • Erythrocyte aggregation is a critical hemorheological parameter with implications for clinical research.
  • Further investigation into the factors influencing erythrocyte aggregation is warranted.
  • The interplay between erythrocyte aggregation and plasma fibrinogen requires continued study.