Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of exercise on complement activity.

J K Smith1, D S Chi, G Krish

  • 1Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City.

Annals of Allergy
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

149&#x2003;Effects of quisqualic acid and L-&#x3b1;-amino butyrate supplementation during <i>in vitro</i> oocyte maturation on embryonic development in pigs.

Reproduction, fertility, and development·2022
Same author

170&#x2003;Acetylation patterns of histone H3K27 in aged pig oocytes.

Reproduction, fertility, and development·2022
Same author

Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2020
Same author

Cognitive behavioral therapy may have a rehabilitative, not normalizing, effect on functional connectivity in adolescent depression.

Journal of affective disorders·2020
Same author

An approach for the identification of exemplar sites for scaling up targeted field observations of benthic biogeochemistry in heterogeneous environments.

Biogeochemistry·2020
Same author

Migrant status and identification as ultra-high risk for psychosis and transitioning to a psychotic disorder.

Acta psychiatrica Scandinavica·2019

Aerobic exercise activates complement pathways, increasing anaphylatoxins C3a and C4a. Asthmatic runners show heightened responses, suggesting a role in exercise-induced asthma.

Area of Science:

  • Immunology
  • Exercise Physiology

Background:

  • The complement system is crucial for immune response.
  • Exercise can modulate immune functions, but its effect on complement pathways is not fully understood.

Purpose of the Study:

  • To investigate the impact of short-term aerobic exercise on complement system activation in experienced runners.
  • To compare complement levels between runners and non-exercisers.
  • To explore complement activation in asthmatic runners during exercise.

Main Methods:

  • Measurement of complement components (C1, C1q, C2, C3, C4, C5), anaphylatoxins (C3a, C4a, C5a), and hemolytic activity (classical and alternative pathways).
  • Analysis of 26 experienced adult runners before and after exercise, compared to age-matched controls.
  • Preliminary assessment in three asthmatic runners.

Related Experiment Videos

Main Results:

  • Running increased C3a and C4a levels and decreased C4 hemolytic activity (C4H).
  • Runners exhibited lower baseline C3 and C4H compared to controls.
  • Asthmatic runners showed significantly higher resting, post-exercise, and exercise-induced C3a levels.

Conclusions:

  • Short-term exercise activates complement C3 and C4, generating C3a and C4a anaphylatoxins.
  • Regular aerobic exercise may involve classical complement pathway activation and C3 downregulation.
  • Exaggerated C3a generation in asthmatic runners suggests a potential role in exercise-induced asthma.