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Methylene iodide poisoning.

P J Weimerskirch1, K K Burkhart, M J Bono

  • 1Department of Emergency Medicine, Eastern Virginia Graduate School of Medicine, Norfolk.

Annals of Emergency Medicine
|October 1, 1990
PubMed
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Methylene iodide ingestion is a potent hepatotoxin, causing liver failure and carbon monoxide poisoning in a child. This case highlights its severe toxicity and need for awareness.

Area of Science:

  • Toxicology
  • Pediatric Medicine
  • Environmental Health

Background:

  • Methylene iodide is a chemical compound with limited reported human toxicity data.
  • Accidental ingestions in children present unique diagnostic and management challenges.

Observation:

  • A 20-month-old child ingested 25 mL of pure methylene iodide, presenting with lethargy, incoordination, and vomiting.
  • Radiographs confirmed the presence of radiopaque methylene iodide in the gastrointestinal tract.
  • Peak carboxyhemoglobin levels reached 14.2%, indicating in vivo conversion to carbon monoxide.

Findings:

  • The patient developed significant hepatotoxicity, progressing to fulminant hepatic failure within two days.
  • Methylene iodide was confirmed as a potent hepatotoxin.

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  • The substance is metabolized to carbon monoxide and is radiopaque, potentially causing bone marrow suppression.

    • Implications:

    • This case represents the first reported human ingestion of methylene iodide.
    • Highlights the critical need for prompt recognition and aggressive supportive care in methylene iodide poisoning.
    • Underscores the potential for severe systemic toxicity, including hepatic and hematologic effects.