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Long-term treatment with beclomethasone dipropionate aerosol in asthmatic children with special reference to growth

V Graff-Lonnevig, S Kraepelien

    Allergy
    |February 1, 1979
    PubMed

    Insights

    Beclomethasone dipropionate aerosol (BDA) treatment for severe childhood asthma did not significantly impact growth or bone age. This asthma medication also reduced hospital admissions by over 50% in the first year.

    Area of Science:

    • Pediatric Pulmonology
    • Pediatric Endocrinology

    Background:

    • Severe perennial bronchial asthma in children requires effective long-term management.
    • Growth and skeletal maturation are critical concerns with long-term corticosteroid use in pediatric patients.

    Purpose of the Study:

    • To evaluate the effect of beclomethasone dipropionate aerosol (BDA) on growth and skeletal maturation in children with severe asthma.
    • To assess the impact of BDA on asthma control and hospital admissions.

    Main Methods:

    • A cohort of 31 children with severe asthma received BDA for 16-40 months.
    • Growth parameters (height) and bone age were monitored before and after treatment.
    • Hospital admission rates were compared before and during BDA therapy.

    Main Results:

    • No significant retardation in height or bone age development was observed during BDA treatment.
    • The mean height deviation from normal Swedish children remained consistent throughout the study.
    • Acute hospital admissions for asthma were reduced by over 50% within the first year of BDA treatment.

    Conclusions:

    • Beclomethasone dipropionate aerosol is a safe treatment for severe childhood asthma, with no adverse effects on growth or skeletal maturation.
    • BDA effectively controls asthma symptoms and significantly reduces the need for hospitalization in pediatric patients.

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