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Updated: May 26, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
A case of idiopathic retroperitoneal fibrosis
Mehmet Altan1, Ashar Usmani, Steven Angelo
1Hospital of Saint Raphael, New Haven, CT 06511, USA.
Abstract:
Retroperitoneal fibrosis is the presence of a fibrotic plaque in the prelumbar or presacral area. It can occur as a result of certain medications, fluid collections, inflammatory disease of various intra-abdominal organs, previous surgery or radiation therapy and various metastatic neoplasms. Most cases of retroperitoneal fibrosis are considered idiopathic. We report an interesting case of idiopathic retroperitoneal fibrosis with the emphasis on the importance of pathology to establish the diagnosis.
Insights
Idiopathic retroperitoneal fibrosis is a rare condition. This case highlights the crucial role of pathology in diagnosing this often-unexplained fibrotic plaque.
Area of Science:
- Medical pathology
- Gastroenterology
- Oncology
Background:
- Retroperitoneal fibrosis involves a fibrotic plaque in the prelumbar/presacral area.
- Causes include medications, fluid collections, intra-abdominal inflammation, surgery, radiation, and metastatic neoplasms.
- However, most cases are idiopathic, meaning the cause is unknown.
Observation:
- This report details an unusual case of idiopathic retroperitoneal fibrosis.
- The case emphasizes the diagnostic challenges and the importance of pathological examination.
Findings:
- Pathology is essential for confirming the diagnosis of idiopathic retroperitoneal fibrosis.
- Histopathological analysis differentiates it from other retroperitoneal masses and inflammatory conditions.
Implications:
- Accurate diagnosis through pathology is critical for appropriate patient management.
- Understanding idiopathic retroperitoneal fibrosis aids in developing targeted treatment strategies.
- This case contributes to the literature on rare fibrotic conditions affecting the retroperitoneum.
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