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Related Experiment Video

Updated: May 26, 2026

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

[Practice guideline 'Brain metastases' (revision)].

J M M Anja Gijtenbeek1, Vincent K Y Ho, M A A M Mart Heesters

  • 1Universitair Medisch Centrum St. Radboud, Nijmegen, the Netherlands. j.gijtenbeek@neuro.umcn.nl

Nederlands Tijdschrift Voor Geneeskunde
|January 6, 2012
PubMed
Summary

Cancer patients surviving longer are more likely to develop brain metastases. Whole brain radiotherapy is not recommended after stereotactic radiosurgery or resection due to toxicity and lack of survival benefit.

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Last Updated: May 26, 2026

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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
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Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Neurosurgery

Context:

  • Increasing cancer survival rates lead to a higher incidence of brain metastases.
  • Active screening detects more asymptomatic brain metastases.
  • Brain MRI is crucial for diagnosing brain metastases in patients with neurological symptoms.

Purpose:

  • To provide updated guidelines for the diagnosis and treatment of brain metastases.
  • To emphasize a multidisciplinary approach in treatment decisions.
  • To clarify the role of whole brain radiotherapy in the management of brain metastases.

Summary:

  • Treatment for brain metastases focuses on preserving neurological function.
  • Key treatment modalities include whole brain radiotherapy, stereotactic radiosurgery/radiotherapy, and neurosurgical resection.
  • Treatment selection is based on metastasis characteristics, patient condition, and extracranial disease extent.

Impact:

  • Revised guidelines suggest whole brain radiotherapy is not standard after stereotactic radiosurgery or radiotherapy.
  • Complete resection confirmed by MRI negates the need for whole brain radiotherapy, avoiding potential toxicity.
  • This impacts treatment protocols, aiming to improve patient outcomes and minimize radiation-induced side effects.