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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Burden of a multiple sclerosis relapse: the patient's perspective
Merrikay Oleen-Burkey1, Jane Castelli-Haley, Maureen J Lage
1Teva Pharmaceuticals, Kansas City, MO, USA.
The Patient
|January 6, 2012
Summary
Multiple sclerosis (MS) relapses significantly increase patient costs and decrease quality of life and functional ability. Understanding these impacts is crucial for managing the disease burden.
Area of Science:
- Neurology
- Health Economics
- Patient-Reported Outcomes
Background:
- Relapsing-remitting multiple sclerosis (RRMS) relapses are common and increase disability.
- Increased disability negatively impacts quality of life, work, and leisure.
- Relapse severity is linked to higher healthcare expenditures.
Purpose of the Study:
- To characterize the patient-reported impact of multiple sclerosis (MS) relapses.
- To assess economic costs, productivity losses, functional ability, and health-related quality of life (HR-QOL) in RRMS patients.
- To analyze data from US patients using immunomodulatory agents.
Main Methods:
- A cross-sectional, web-based, self-report survey was administered to RRMS patients in the US.
- Data collected on healthcare resource utilization, community services, and assistive items.
- Work and Leisure Impairment instrument, EQ-5D, and Goodin MS questionnaire were utilized.
Main Results:
- 67% of patients reported at least one relapse annually (mean 2.2).
- Relapsing patients incurred higher annual costs ($38,458 vs $28,669), driven by direct health costs and indirect costs.
- Relapse was associated with higher disability (EDSS 4.3 vs 3.7) and lower HR-QOL (0.66 vs 0.75).
Conclusions:
- MS relapses significantly increase economic costs from a patient's perspective.
- Relapses lead to a decline in health-related quality of life (HR-QOL).
- Functional ability is diminished during MS relapses.
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