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Related Experiment Video

Updated: May 26, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Transmyocardial laser revascularization. Personal experience.

F Sansone¹, G M Actis Dato, E Zingarelli

¹Mauriziano Umberto I"Hospital, Turin, Italy.

Il Giornale Di Chirurgia

|January 6, 2012

Summary

This summary is machine-generated.

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Transmyocardial revascularization (TMR) is a safe and feasible treatment for severe, untreatable angina. This laser therapy improves heart perfusion and reduces symptoms, offering a therapeutic solution when other methods fail.

Area of Science:

Cardiovascular Surgery
Interventional Cardiology

Background:

Severe angina often necessitates indirect revascularization when direct surgical or percutaneous options are unsuitable.
Transmyocardial revascularization (TMR) utilizes laser energy to create channels in the left ventricle, promoting angiogenesis and reducing cardiac nerve fibers.

Purpose of the Study:

To evaluate the safety and efficacy of Transmyocardial Revascularization (TMR) as a therapeutic option for patients with severe angina unresponsive to conventional treatments.
To assess the feasibility of TMR as a standalone procedure or as a hybrid approach in conjunction with Coronary Artery Bypass Grafting (CABG).

Main Methods:

Fourteen patients with severe angina (Canadian Angina Class III-IV) underwent TMR.
Coronary angiography revealed that 91.6% of patients had coronary artery lesions unsuitable for direct revascularization (CABG).

Related Experiment Videos

Last Updated: May 26, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

One patient received a combined TMR + CABG procedure.

Main Results:

Patients experienced a mean hospital stay of 3.2 days and were discharged in good condition.
Follow-up scintigraphy in 7 patients showed improved myocardial perfusion in all but one.
Exercise treadmill tests indicated functional improvement, with reduced medication dependence.

Conclusions:

TMR is a safe and feasible procedure for managing untreatable angina.
TMR offers a viable therapeutic solution for refractory angina.
TMR can be employed as a hybrid strategy in CABG when direct revascularization is limited.