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Related Experiment Video

Updated: May 26, 2026

Iris Fixation via External Pentagram Suturing

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Published on: May 5, 2022

Cefixime-induced oculogyric crisis.

Erhan Bayram¹, Meral Torun Bayram, Semra Hiz

¹Department of Pediatric Neurology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. dr.erhanbayram@yahoo.com

Pediatric Emergency Care

|January 6, 2012

Summary

This summary is machine-generated.

A 7-year-old boy experienced an oculogyric crisis, a rare neurologic event, after taking cefixime for a urinary tract infection. Symptoms resolved within 48 hours of discontinuing the antibiotic.

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Area of Science:

Neurology
Pharmacology
Pediatrics

Background:

Oculogyric crisis is a neurologic adverse event involving abnormal eye movements.
Cefixime, a third-generation cephalosporin, is commonly used in pediatric urinary tract infections.
Cephalosporins are associated with various neurologic adverse events, including seizures and encephalopathy.

Observation:

A 7-year-old boy developed an oculogyric crisis during cefixime treatment for a urinary tract infection.
The crisis presented as bilateral, upward, conjugate eye deviations.
This represents the first reported case of cefixime-induced oculogyric crisis in a child.

Findings:

Cefixime administration was temporally associated with the onset of oculogyric crisis.
Ocular symptoms resolved gradually within 48 hours after cefixime discontinuation.
This case highlights a potential, albeit rare, neurologic adverse effect of cefixime.

Implications:

Clinicians should be aware of the potential for cefixime to induce oculogyric crisis in children.
Prompt recognition and discontinuation of cefixime may lead to rapid resolution of symptoms.
Further investigation into the neurotoxicity of cephalosporins, including cefixime, is warranted.