Related Experiment Video
Updated: May 26, 2026
09:19
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
Arterial endothelial dysfunction and idiopathic deep venous thrombosis
G Mazzoccoli1, M Grilli, F Ferrandino
1Unit of Internal Medicine, Department of Medical Sciences, Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. g.mazzoccoli@tin.it
Journal of Biological Regulators and Homeostatic Agents
|January 6, 2012
Summary
Patients with deep venous thrombosis (DVT) show impaired arterial endothelial function, indicated by lower Flow Mediated Dilation (FMD). This dysfunction is an independent predictor of increased cardiovascular risk in DVT patients.
Area of Science:
- Cardiovascular Medicine
- Vascular Biology
- Epidemiology
Background:
- Deep venous thrombosis (DVT) is linked to a higher risk of subsequent atherosclerotic disease.
- Arterial endothelial dysfunction is a key predictor of future ischemic cardiovascular events.
- Flow Mediated Dilation (FMD) is a measure of endothelial function.
Purpose of the Study:
- To evaluate arterial endothelial function, assessed by FMD, in patients with idiopathic DVT.
- To determine if DVT is an independent predictor of impaired FMD.
- To identify the association between DVT, endothelial dysfunction, and cardiovascular risk.
Main Methods:
- FMD was measured in the brachial artery of 60 idiopathic DVT patients and 60 controls with similar cardiovascular risk profiles.
- Statistical analyses included univariate and multivariate linear and logistic regression models.
- Receiver Operating Characteristic (ROC) curve analysis was used to determine a cut-off value for impaired FMD.
Main Results:
- Idiopathic DVT patients exhibited significantly lower FMD compared to controls (6.78% vs 10.88%, p<0.001).
- In multivariate analysis, DVT was the sole independent predictor of lower FMD (p<0.001).
- An FMD cut-off of ≤8.5% was more frequent in DVT patients (71.67% vs 41.67%, p<0.001), with DVT being the unique independent predictor.
Conclusions:
- Deep venous thrombosis is associated with impaired arterial endothelial function.
- Impaired FMD in DVT patients serves as a marker for increased future cardiovascular risk.
- These findings underscore the importance of assessing endothelial health in DVT management.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
01:19Pulmonary Embolism I: Introduction
A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...