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Related Experiment Videos

Oral glucose tolerance test--can the reflectance meter replace laboratory-based methods?

K T Tan1, A A Hsu, K W Wang

  • 1Department of Medicine I, Singapore General Hospital.

Annals of the Academy of Medicine, Singapore
|July 1, 1990
PubMed
Summary

Capillary blood glucose testing for oral glucose tolerance tests showed significant variability in classifying diabetes and impaired glucose tolerance. Laboratory-based venous blood glucose measurements are more reliable for accurate diagnosis.

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Area of Science:

  • Clinical Chemistry
  • Endocrinology
  • Diagnostic Testing

Background:

  • Glycosuria, or glucose in the urine, can indicate underlying metabolic issues.
  • Accurate glucose monitoring is crucial for diagnosing and managing diabetes and impaired glucose tolerance.
  • Different methods for measuring blood glucose may yield varying diagnostic results.

Purpose of the Study:

  • To compare the diagnostic accuracy of capillary blood glucose measurements using a reflectance meter against laboratory-based venous blood glucose analysis.
  • To evaluate the consistency of classification for diabetes and impaired glucose tolerance across different glucose testing methods.

Main Methods:

  • Sixteen national servicemen with glycosuria underwent three successive oral glucose tolerance tests (oGTT).

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  • Capillary blood glucose was measured using a reflectance meter (oGTT1, oGTT3).
  • Venous whole blood glucose was analyzed via a laboratory-based method (oGTT2, oGTT3).

    • Main Results:

    • Initial testing (oGTT1) classified 1 subject as diabetic and 15 as having impaired glucose tolerance (IGT).
    • Subsequent tests showed considerable variation in classification depending on the method used.
    • Capillary blood glucose measurements resulted in higher rates of IGT classification compared to venous blood analysis.

    Conclusions:

    • There is significant variation in classifying diabetes and impaired glucose tolerance when using capillary blood glucose measured by a reflectance meter compared to laboratory methods.
    • Capillary blood glucose measurement using a reflectance meter is not recommended for oral glucose tolerance testing due to inconsistent results.