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Related Experiment Videos

An amperometric measurement--the ExacTech pen meter.

K F Lui1, W Y Ng, A C Thai

  • 1Department of Medicine, National University of Singapore.

Annals of the Academy of Medicine, Singapore
|July 1, 1990
PubMed
Summary

The ExacTechR blood glucose meter offers simple self-monitoring for diabetics. While precise, its accuracy varies with glucose levels and is affected by anticoagulants.

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Area of Science:

  • Biomedical Engineering
  • Clinical Chemistry

Background:

  • Self-monitoring of blood glucose is crucial for diabetes management.
  • New devices aim to improve accuracy and user-friendliness for diabetic patients.

Purpose of the Study:

  • To evaluate the technical performance (precision and accuracy) of the ExacTechR blood glucose meter.
  • To compare the ExacTechR's results with a reference analyzer.
  • To assess the impact of anticoagulants on ExacTechR measurements.

Main Methods:

  • Amperometric measurement device (ExacTechR) evaluated.
  • 174 venous blood samples analyzed (range 26-412 mg/dL).
  • Precision assessed across seven glucose concentrations (52-300 mg/dL).
  • Effect of fluoride-oxalate, EDTA, and heparin on measurements studied.

Main Results:

  • ExacTechR showed acceptable accuracy for blood glucose >151 mg/dL, but was less accurate below 150 mg/dL.
  • Average coefficient of variation (CV) for precision was 4.3% (range 2.6-5.2%).
  • Anticoagulants significantly altered results: fluoride-oxalate (+22%), EDTA (-4%), heparin (-1.9%).

Conclusions:

  • The ExacTechR meter provides precise blood glucose readings but exhibits variable accuracy, particularly at lower concentrations.
  • The presence of anticoagulants like fluoride-oxalate, EDTA, and heparin can significantly interfere with ExacTechR measurements.
  • Further validation is needed for reliable use across diverse sample types and glucose ranges in diabetic self-monitoring.

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