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Updated: May 26, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Multiple myeloma presenting as acute tubulointerstitial nephritis and normal serum protein electrophoresis
Ali Momeni1, Ali Hajigholami, Hamid Nasri
1Division of Nephrology, Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. ali.momeny@yahoo.com
Abstract:
Multiple myeloma is uncommon in individuals younger than 40 years. Renal involvement is common in this disease, but acute tubulointerstitial nephritis is very rare. In 20% of patients, only the light chain is produced and serum protein electrophoresis is normal; however, in urine protein electrophoresis of these patients, the M spike is present. We reported a case of multiple myeloma in a 39-year-old man with acute tubulointerstitial nephritis. Serum protein electrophoresis was normal and there was no bone lytic lesion. Remission of multiple myeloma was achieved after treatment with thalidomide and dexamethasone; however, kidney failure was not improved and the patient was maintained on hemodialysis.
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