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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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Published on: January 12, 2022

Acquired vitelliform lesion associated with large drusen.

Luiz H Lima¹, Ketan Laud, K Bailey Freund

¹Vitreous, Retina, Macula Consultants of New York, New York, NY, USA.

Retina (Philadelphia, Pa.)

|January 6, 2012

Summary

Acquired vitelliform lesions (AVL) can occur with large drusen in non-neovascular age-related macular degeneration. This association suggests shared underlying pathological processes in macular degeneration.

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Area of Science:

Ophthalmology
Retinal Diseases
Age-Related Macular Degeneration

Background:

Non-neovascular age-related macular degeneration (AMD) is a leading cause of vision loss.
Acquired vitelliform lesions (AVL) are typically associated with specific forms of drusen.
The relationship between AVL and large drusen in non-neovascular AMD requires further elucidation.

Purpose of the Study:

To describe the association between acquired vitelliform lesions (AVL) and large drusen.
To investigate the characteristics of AVL in patients with non-neovascular age-related macular degeneration and large drusen.

Main Methods:

Retrospective review of clinical and multimodal imaging data.
Defined AVL as subretinal hyperautofluorescent material.
Diagnosed large drusen using multimodal imaging (color photography, autofluorescence, SD-OCT).

Main Results:

Thirteen eyes (9 patients) with AVL and large drusen were identified.
Median visual acuity was 20/60.
AVLs were hyperautofluorescent and located between RPE and photoreceptors, similar to AVL with other drusen types.

Conclusions:

Acquired vitelliform lesions (AVL) can be associated with large drusen in non-neovascular AMD.
This finding expands the known associations of AVL.
Potential shared or parallel pathophysiological mechanisms may underlie both AVL and drusen formation.