[Induction of ovulation, with pulsatile GnRH by subcutaneous route in amenorrhea of hypothalamic origin]

Twelve patients affected by secondary amenorrhea of hypothalamic origin, resistant to Clomiphene Citrate treatment, were treated for 2 consecutive cycles with subcutaneous pulsatile administration (s.c.) of Gn-RH by computerized portable pump (Ziklomat-Ferring) at a dose of 20 mcg every 60-90 minutes for a total of 20 cycles. On the average 85% of ovulatory cycles and 30% of pregnancies per cycle were obtained with this therapy. The number of ovulatory cycles and pregnancies obtained in the second cycle of treatment were in percentage higher, with respect to the first cycle of treatment. Only one subject, not responsive to both cycles of s.c. administration, underwent an intravenous therapy with positive results.