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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular
Laxmi Gella1, Rajiv Raman, Swakshyar Saumya Pal
1Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Purpose:
To evaluate the relationship between the morphology and retinal function of macular microhole (MMH) variants.
Materials And Methods:
We evaluated 12 eyes of 11 patients with defects in the IS/OS junction of photoreceptor layer with SD-OCT. All patients underwent comprehensive ophthalmic examination including spectral domain optical coherence tomography (SD-OCT) and microperimetry.
Results:
The mean logMAR visual acuity in the affected eye was 0.15 ± 0.17 (range 0.00-0.5). Mean horizontal diameter of the MMH was 163 ± 99 μm; the mean retinal sensitivity in the area corresponding to the MMH was 13.79 ± 4.6 dB. Negative correlation was found between the MMH diameter and the retinal sensitivity (r = -0.65, P = 0.02). Three morphological patterns of MMH variants were recognized on SD-OCT, which did not differ in retinal sensitivities.
Conclusion:
We described and classified the MMH variants and made an assessment on the physiological functions using microperimeter.

