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Updated: May 26, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Chloro-N'-(2-hy-droxy-4-meth-oxy-benzyl-idene)benzohydrazide methanol monosolvate
Feng Zhi1, Rong Wang, Yi Zhang
1Third Affiliated Hospital of Suzhou University, Changzhou 213000, People's Republic of China.
Abstract:
The title compound, C(15)H(13)ClN(2)O(3)·CH(3)OH, was synthesized by the condensation reaction of 2-hy-droxy-4-meth-oxy-benzaldehyde with 4-chloro-benzohydrazide in methanol. The Schiff base mol-ecule displays a trans configuration with respect to the C=N and C-N bonds. The dihedral angle between the two benzene rings is 5.3 (2)°. In the crystal, mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen-bond inter-actions into chains running parallel to the a axis. An intra-molecular O-H⋯N hydrogen bond is observed.
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