Related Experiment Video
Updated: May 26, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
2-(2-Bromo-eth-yl)isoindoline-1,3-dione.
Xiao-Qiang Sun1, Dong An, Ying Shao
1Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, Jiangsu, People's Republic of China.
This study details the crystal structure of a brominated organic compound, C(10)H(8)BrNO(2), revealing three independent molecules with varying side-chain conformations. The crystal packing is influenced by Br⋯O contacts, hydrogen bonds, and π-π stacking interactions.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Understanding the solid-state structure of organic compounds is crucial for predicting their physical and chemical properties.
- The presence of bromine and nitro groups suggests potential applications in areas like flame retardants or pharmaceuticals.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(10)H(8)BrNO(2).
- To analyze the molecular conformations and intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of bond lengths, torsion angles, and intermolecular contacts (Br⋯O, C-H⋯O, π-π stacking) was performed.
Main Results:
- The asymmetric unit contains three crystallographically independent molecules.
- Two N-C-C-Br side chains exhibit anti conformations, while one displays a gauche conformation.
- Significant intermolecular interactions include short Br⋯O contacts, C-H⋯O hydrogen bonds, and π-π stacking.
Conclusions:
- The crystal structure of C(10)H(8)BrNO(2) is characterized by conformational diversity in its side chains.
- Intermolecular forces, particularly Br⋯O contacts and π-π stacking, play a key role in stabilizing the crystal packing.
- This detailed structural information provides a foundation for further investigations into the compound's properties and potential applications.
More Related Videos
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
14:11Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Halogenation of Alkenes
Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Formation of Halohydrin from Alkenes
NMR Spectroscopy of Benzene Derivatives