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Updated: May 26, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

4-Chloro-6,7-dimeth-oxy-quinoline.

¹School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|January 6, 2012

Summary

This summary is machine-generated.

This study details the molecular structure of C(11)H(10)ClNO(2), revealing an almost planar quinoline ring system. An intramolecular interaction forms a specific ring motif, offering insights into chemical bonding.

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Area of Science:

Organic Chemistry
Crystallography

Background:

Understanding molecular geometry and bonding is crucial in organic chemistry.
Quinoline derivatives are important scaffolds in medicinal chemistry and materials science.

Purpose of the Study:

To elucidate the precise three-dimensional structure of the title molecule, C(11)H(10)ClNO(2).
To investigate the presence and implications of intramolecular interactions within the molecule.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the molecular structure.
Analysis of atomic deviations from the least-squares plane of the quinoline ring system.

Main Results:

The molecule exhibits an almost planar quinoline ring system with a root-mean-square deviation of 0.002 Å.
Methoxy group carbon atoms show minimal deviation from the ring plane.
An intramolecular C-H⋯Cl interaction was identified, forming an S(5) ring motif.

Conclusions:

The structural analysis confirms the near-planarity of the quinoline core in C(11)H(10)ClNO(2).
The observed intramolecular C-H⋯Cl interaction plays a role in stabilizing the molecular conformation.