High throughput screening technology and the small molecules modulating aging related signals.

Area of Science:

• Pharmacology and Drug Discovery
• Biogerontology
• Biochemistry

Background:

• Aging and its associated diseases pose significant societal challenges.
• Identifying therapeutic compounds for aging is complex due to numerous involved pathways.
• Recent advancements in high throughput screening (HTS) have accelerated the discovery of small molecules targeting aging.

Purpose of the Study:

• To review the workflow, classification, and assay strategies of HTS in aging research.
• To categorize small molecules identified through HTS based on their roles in age-related diseases.
• To provide an overview of aging mechanisms and compounds modulating key aging signals.

Main Methods:

• Review of current literature on HTS technologies and their application in aging.
• Classification of identified small molecules by their therapeutic targets in aging-related diseases.
• Summary of cellular aging mechanisms and relevant compound modulators.

Main Results:

• HTS has successfully identified numerous small molecules targeting aging-related pathologic processes.
• Identified compounds show potential in addressing diseases such as neurodegeneration, diabetes, and tumors.
• The application of HTS in aging research is a rapidly developing field.

Conclusions:

• HTS is a powerful tool for discovering anti-aging compounds.
• Further integration of HTS with aging biology research is crucial for therapeutic advancements.
• This review offers valuable insights for researchers in pharmacology, HTS, and aging biology.