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Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen
E Hamsíková1, H Závadová, L Kutinová
1Department of Experimental Virology, Institute of Sera and Vaccines, Prague, Czechoslovakia.
Archives of Virology
|January 1, 1990
Abstract:
Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.