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Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
1Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.
Archives of Virology
|January 1, 1990
Abstract:
After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent "immunostimulating complex" induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.