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Measuring Psoriasis Severity at Home
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Coronary artery disease in patients with psoriasis referred for coronary angiography

April W Armstrong1, Caitlin T Harskamp, Lynda Ledo

  • 1Department of Dermatology, University of California Davis, Sacramento, USA. aprilarmstrong@post.harvard.edu

The American Journal of Cardiology
|January 7, 2012
PubMed

Insights

Psoriasis patients have a higher risk of coronary artery disease (CAD). This study found psoriasis is independently linked to CAD, especially when present for over 8 years, even after accounting for other risk factors.

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • Psoriasis is a chronic inflammatory disease.
  • Patients with psoriasis may face an elevated risk of cardiovascular disease (CVD), including myocardial infarction.
  • The association between psoriasis and coronary artery disease (CAD) independent of traditional CVD risk factors requires further investigation.

Purpose of the Study:

  • To determine if psoriasis is associated with a higher prevalence of CAD.
  • To assess if this association persists independently of established cardiovascular risk factors.
  • To examine the impact of psoriasis duration on CAD prevalence.

Main Methods:

  • Retrospective cohort analysis linking coronary angiography records (2004-2009) with dermatology records.
  • Identified 204 patients with psoriasis from a cohort of 9,473 patients undergoing coronary angiography.
  • Statistical analysis adjusted for established cardiovascular risk factors.

Main Results:

  • Patients with psoriasis showed a higher prevalence of CAD (84.3% vs 75.7%, p = 0.005).
  • Psoriasis was independently associated with angiographically confirmed CAD (adjusted odds ratio 1.8, p = 0.006).
  • Psoriasis duration exceeding 8 years was also independently linked to CAD (adjusted odds ratio 3.5, p = 0.02).

Conclusions:

  • Psoriasis is independently associated with a higher prevalence of CAD in patients undergoing coronary angiography.
  • Patients with psoriasis, particularly those with disease duration over 8 years, exhibit increased CAD prevalence.
  • These findings highlight the importance of cardiovascular risk assessment in psoriasis patients.

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