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Updated: May 26, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Synthesis and DNA cleavage studies of novel quinoline oxime esters
P J Bindu1, K M Mahadevan, N D Satyanarayan
1Department of Studies and Research in Chemistry, Kuvempu University, Shankaraghatt 577 451, India. bindu12_naik@rediffmail.com
Abstract:
New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0°C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form.
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