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Muscarinic modulation of striatal function and circuitry
Joshua A Goldberg1, Jun B Ding, D James Surmeier
1Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Handbook of Experimental Pharmacology
|January 7, 2012
Summary
Cholinergic interneurons in the striatum modulate action selection. This review highlights muscarinic and nicotinic receptor roles in synaptic plasticity and behavior, emphasizing patterned neural activity.
Area of Science:
- Neuroscience
- Cellular Signaling
- Systems Neuroscience
Background:
- Striatal cholinergic interneurons are key regulators of striatal circuits.
- These neurons influence action selection and decision-making processes.
- Both muscarinic and nicotinic receptors are involved in acetylcholine signaling within the striatum.
Purpose of the Study:
- To review the effects of muscarinic receptor signaling on striatal principal cells and circuits.
- To highlight new insights into the role of muscarinic signaling in synaptic integration and plasticity.
- To discuss the impact of nicotinic receptor activation on striatal circuit elements.
Main Methods:
- Literature review of studies on muscarinic and nicotinic receptor signaling in the striatum.
- Analysis of research on synaptic integration and plasticity.
- Examination of circuit elements influenced by cholinergic activity.
Main Results:
- Muscarinic receptor signaling significantly impacts striatal cell types and canonical circuits.
- New evidence reveals roles for muscarinic signaling in synaptic integration and plasticity.
- Nicotinic receptor activation drives novel striatal circuit elements.
Conclusions:
- Temporally patterned activity of cholinergic interneurons is crucial for striatal circuitry modulation.
- Cholinergic signaling influences synaptic integration and plasticity.
- These mechanisms are vital for behavioral responses to salient environmental stimuli.
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