Crystal-like deposits of amyloid in pancreatic islet cell tumors

Numerous stellate crystal-like deposits of amyloid were observed in four human pancreatic islet cell tumors. Three of the tumors were associated with hypoglycemia or hyperinsulinemia, and the remaining one produced gastrin. Histochemical and ultrastructural studies confirmed the existence of amyloid in the deposits and also suggested the presence of adsorbed or incorporated mucopolysaccharides. Stellate amyloid deposits have previously been described in experimental systemic murine amyloidosis. The relationships of these stellate deposits to other forms of amyloid depostion are unknown.