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Retinal thickness changes following photodynamic therapy in chronic central serous chorioretinopathy
Sergio Copete1, Jose M Ruiz-Moreno, Carlos Cava
1Castilla La Mancha University, Albacete, Spain. sergiocp.ab@gmail.com
Objective:
To evaluate changes in neural retina (NR) thickness and best-corrected visual acuity (BCVA) induced by treatment of chronic central serous chorioretinopathy (CSC) by photodynamic therapy (PDT).
Patients And Methods:
Retrospective study of 25 eyes of 25 patients with chronic CSC treated by "full-fluence" PDT. LogMAR BCVA and Stratus optical coherence tomography (OCT) were evaluated before treatment and 1 year after PDT. Twenty-four eyes from 24 patients with non-chronic, non-PDT-treated forms of CSC were evaluated as a control group.
Results:
NR foveal thickness before PDT was 182 ± 43.4 μm (range, 92-246) vs 148.1 ± 30.9 μm (range, 101-220) 1 year after treatment (p = 0.004; Student's t-test paired data). NR foveal thickness in the untreated eyes was 204.6 ± 30.7 μ (range, 132-249) vs 192.5 ± 26.4 μ (range, 123-235) after self-resolution (p = 0.03; Student's t-test paired data). Basal NR thickness was statistically significant different between both groups (p = 0.04; Student's t-test); this difference continued to be significant at the end of the follow-up (p < 0.01; Student's t-test). All the patients with chronic CSC treated by PDT showed anatomic resolution, and BCVA improved from 0.38 ± 0.35 to 0.23 ± 0.29 (p = 0.007; Student's t-test paired data). Final BCVA and basal and final NR thickness showed poor correlation (Pearson = 0.2 and 0.1 respectively).
Conclusions:
The use of PDT in chronic CSC induces NR thickness thinning. This change is not correlated with a decrease in BCVA. Spontaneous resolution of classic CCS also showed significant NR thinning.