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Related Experiment Video

Updated: May 26, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye

Published on: September 5, 2011

Variable presentations of postpartum angiopathy.

Jennifer E Fugate1, Sebastián F Ameriso, Gustavo Ortiz

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Stroke
|January 7, 2012
PubMed
Summary
This summary is machine-generated.

Postpartum angiopathy (PPA) can cause severe neurological symptoms and is not always benign. This study found a higher proportion of non-benign outcomes in patients with PPA, including stroke and edema.

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Last Updated: May 26, 2026

Accurate and Simple Evaluation of Vascular Anastomoses in Monochorionic Placenta using Colored Dye
09:52

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Published on: September 5, 2011

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Area of Science:

  • Neurology
  • Obstetrics
  • Radiology

Background:

  • Postpartum angiopathy (PPA) is a rare condition causing stroke in the puerperium.
  • Characterized by severe headaches and segmental vasoconstriction on angiography.
  • Previously considered a benign condition.

Purpose of the Study:

  • To define clinical presentations, radiological findings, and outcomes of PPA patients.
  • To investigate the clinical course and prognosis of postpartum angiopathy.
  • To challenge the notion of PPA as a universally benign condition.

Main Methods:

  • Retrospective review of 18 patients from 3 centers.
  • Inclusion criteria: acute neurological symptoms and postpartum angiography showing vasoconstriction.
  • Exclusion criteria: no neuroimaging, cerebral venous sinus thrombosis, aneurysmal hemorrhage.

Main Results:

  • 18 patients (mean age 31) presented with headache, focal deficits, visual disturbances, encephalopathy, or seizures.
  • Neuroimaging revealed abnormalities in 72%, including intracranial hemorrhage (39%), vasogenic edema (35%), and infarction (35%).
  • Outcomes varied: 50% full recovery, 22% death, 28% residual deficits.

Conclusions:

  • Contrary to previous reports, PPA can have a significant proportion of non-benign outcomes.
  • Parenchymal abnormalities on neuroimaging are common in PPA.
  • Stroke (hemorrhagic or ischemic) and reversible vasogenic edema are the most frequent abnormalities.