LTBPs, more than just an escort service
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Updated: May 26, 2026

Quasi-light Storage for Optical Data Packets
Published on: February 6, 2014
Vesna Todorovic1, Daniel B Rifkin
1Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA. vesna.todorovic@nyumc.org
Abstract:
Latent transforming growth factor beta (TGF-β) binding proteins (LTBPs) are large extracellular glycoproteins structurally similar to fibrillins. They perform intricate and important roles in the extracellular matrix (ECM) and perturbations of their function manifest as a wide range of diseases. LTBPs are major regulators of TGF-β bioavailability and action. In addition, LTBPs interact with other ECM proteins-from cytokines to large multi-factorial aggregates like microfibrils and elastic fibers, affecting their genesis, structure, and performance. In the present article, we review recent advancements in the field and relate the complex roles of LTBP in development and homeostasis.
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