Related Experiment Video
Updated: May 26, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals
1Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, The Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, China.
Abstract:
It has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy homeostasis, insulin secretion, and sensitivity, suggesting that ATF4 is a master regulator of metabolism. This review summarizes the most recent progress in the understanding of the novel roles of ATF4 in the regulation of metabolism.
Related Concept Videos
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
General Transcription Factors
Transcription Factors
