Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trajectories of child emotional and behavioural difficulties before and during the COVID-19 pandemic in a longitudinal UK cohort.

JCPP advances·2026
Same author

The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.

JCPP advances·2026
Same author

Birth Weight Percentiles and Infant and Child Growth Dynamics.

JAMA network open·2026
Same author

Capturing infant and child growth dynamics with P-splines mixed effects models.

International journal of obesity (2005)·2026
Same author

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study.

Journal of the American College of Cardiology·2026
Same author

Childhood ADHD and autism spectrum disorder difficulties: exploring the impact of copy number variants on young adult outcomes.

BJPsych open·2026

Related Experiment Video

Updated: Nov 23, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

897

Missing data in trial-based cost-effectiveness analysis: the current state of play.

Sian Marie Noble1, William Hollingworth, Kate Tilling

  • 1School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, UK. s.m.noble@bristol.ac.uk

Health Economics
|January 7, 2012
PubMed
Summary

Complete case analysis is common in randomized controlled trial (RCT)-based cost-effectiveness analyses despite risks. Improved reporting of missing data methods and sensitivity analyses are needed for transparency in healthcare technology assessment.

More Related Videos

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.9K
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.2K

Related Experiment Videos

Last Updated: Nov 23, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

897
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.9K
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

6.2K

Area of Science:

  • Health Economics
  • Biostatistics
  • Clinical Trials Methodology

Background:

  • Randomized controlled trials (RCTs) are increasingly used for cost-effectiveness analyses (CEAs) in healthcare technology assessment.
  • These analyses are often affected by missing data, necessitating robust methodological handling.
  • Existing literature highlights a need for improved approaches to managing missing data in CEAs.

Purpose of the Study:

  • To review the methodology for handling missing data in RCT-based CEAs published since 2003.
  • To assess the prevalence and reporting of missing data handling techniques in this field.
  • To identify areas for improvement in transparency and methodological rigor.

Main Methods:

  • Systematic literature review of RCT-based CEAs published from 2003 onwards.
  • Analysis of the methods used to address missing data.
  • Evaluation of the reporting quality regarding missing data and sensitivity analyses.

Main Results:

  • Complete case analysis remains the most frequent method, despite its potential to yield inappropriate conclusions, and its use has increased over time.
  • Reporting of the extent of missing data and the specific methodologies employed was often inadequate.
  • Transparency regarding missing data sensitivity analyses was frequently lacking.

Conclusions:

  • The continued reliance on complete case analysis in RCT-based CEAs is concerning due to potential biases.
  • There is a critical need for clearer reporting standards and the consistent application of appropriate missing data methodologies.
  • Enhanced transparency through the reporting of missing data sensitivity analyses is crucial for reliable healthcare technology assessment.