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Related Concept Videos

A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine04:06

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Related Experiment Video

Updated: Jan 20, 2026

Three-Dimensional, Serum-Free Culture System for Lacrimal Gland Stem Cells
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Lacrimal glands: size does matter!

Suyash Mohan1, Amogh Hegde, C C Tchoyoson Lim

  • 1Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

Middle East African Journal of Ophthalmology
|January 7, 2012
PubMed
Summary

Sarcoidosis can initially present as isolated lacrimal gland enlargement, causing headaches and blurred vision. Advanced brain MRI and biopsy confirmed this rare initial presentation, highlighting imaging

Keywords:
Lacrimal GlandMagnetic Resonance ImagingSarcoidosis

More Related Videos

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Superior Lacrimal Gland Removal: A Surgical Technique to Remove the Palpebral and Orbital Parts of Superior Lacrimal Gland from Rabbit Model
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Area of Science:

  • Ophthalmology
  • Neurology
  • Pathology

Background:

  • Sarcoidosis is a multisystem inflammatory disease of unknown cause.
  • Ocular adnexal involvement, particularly lacrimal gland enlargement, is an uncommon manifestation of sarcoidosis.
  • Early diagnosis of sarcoidosis is crucial for timely management and preventing complications.

Purpose of the Study:

  • To report a rare case of sarcoidosis presenting solely with lacrimal gland enlargement.
  • To emphasize the role of advanced neuroimaging in diagnosing unsuspected cases of sarcoidosis.
  • To highlight the importance of detailed orbital imaging in identifying pathological causes of lacrimal gland enlargement.

Main Methods:

  • A 40-year-old woman with headaches and blurred vision underwent contrast-enhanced magnetic resonance imaging (MRI) of the brain.
  • MRI revealed bilateral, symmetrical enlargement of the lacrimal glands.
  • A fine needle biopsy of the lacrimal gland was performed for histopathological examination.

Main Results:

  • MRI demonstrated diffuse, symmetrical enlargement of both lacrimal glands.
  • Lacrimal gland biopsy confirmed the diagnosis of sarcoidosis.
  • The patient's symptoms were attributed to this initial, isolated manifestation of sarcoidosis.

Conclusions:

  • Isolated lacrimal gland sarcoidosis, though rare, can be the initial presentation of the disease.
  • Advanced orbital imaging techniques, including thin-section, fat-suppressed MRI, are vital for diagnosis.
  • Prompt recognition and diagnosis of lacrimal gland sarcoidosis can prevent diagnostic delays and guide appropriate treatment.