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Asymptomatic infection of mouse hepatitis virus in the rat. Brief report
Archives of Virology
|January 1, 1979
Abstract:
After intranasal inoculation of suckling rats mouse hepatitis virus multiplied mostly in the nasal epithelium; though there were no symptoms, antibodies were produced. Antibodies were also demonstrated in adult rats. These findings suggest that the rat may be a natural host for the virus.
Insights
Suckling rats infected with mouse hepatitis virus developed antibodies without symptoms, indicating rats may be a natural host for this virus. This research highlights potential viral reservoirs in rodent populations.
Area of Science:
- Virology
- Immunology
- Rodent Pathogen Research
Background:
- Mouse hepatitis virus (MHV) is a significant pathogen in laboratory mice.
- Understanding potential reservoirs for MHV is crucial for disease control and research integrity.
Purpose of the Study:
- To investigate the susceptibility of rats to mouse hepatitis virus.
- To determine the viral replication and immune response in rats following intranasal inoculation.
Main Methods:
- Suckling and adult rats were inoculated intranasally with mouse hepatitis virus.
- Viral multiplication was assessed in nasal epithelium.
- Antibody production was measured in inoculated rats.
Main Results:
- Mouse hepatitis virus replicated primarily in the nasal epithelium of suckling rats.
- Infection occurred without observable clinical symptoms in young rats.
- Antibodies against mouse hepatitis virus were detected in both suckling and adult rats.
Conclusions:
- Rats can be infected with mouse hepatitis virus, replicating the virus in their nasal passages.
- The development of antibodies suggests an immune response, even in the absence of symptoms.
- These findings propose that rats may serve as a natural host for mouse hepatitis virus, warranting further investigation.