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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Humoral Immune Responses01:36

Humoral Immune Responses

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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Updated: May 26, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Pathogenesis of human B cell lymphomas.

Arthur L Shaffer1, Ryan M Young, Louis M Staudt

  • 1Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Annual Review of Immunology
|January 10, 2012
PubMed
Summary

B cell lymphomas hijack normal B cell processes for growth. Understanding these mechanisms, including genetic mutations and signaling pathway alterations, is key to developing targeted cancer therapies.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Published on: March 30, 2018

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13:27

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Published on: October 16, 2009

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08:25

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Published on: January 22, 2021

Area of Science:

  • Immunology
  • Oncology
  • Genetics

Background:

  • B cells possess unique machinery for antibody diversification, which can lead to oncogenic mutations and chromosomal translocations.
  • B cell lymphomas exploit normal B cell differentiation and activation pathways for uncontrolled proliferation and survival.
  • The susceptibility of B cells to malignant transformation is linked to their inherent biological processes.

Purpose of the Study:

  • To elucidate the oncogenic mechanisms driving B cell lymphomas.
  • To understand how normal B cell signaling and regulatory systems are subverted in malignancies.
  • To identify pathogenic principles for the development of targeted therapies.

Main Methods:

  • Utilizing insights from functional and structural genomics to study lymphomagenesis.
  • Analyzing aberrant signaling pathways in B cell malignancies.
  • Investigating alterations in transcriptional regulatory systems and epigenetic modifiers.

Main Results:

  • B cell lymphomas co-opt normal B cell differentiation and activation pathways.
  • Genomic instability, including translocations and mutations, contributes to B cell transformation.
  • Constitutive activation of prosurvival pathways results from derailed antigen-sensing mechanisms.
  • Alterations in epigenetic regulators and transcriptional systems are common in these cancers.

Conclusions:

  • Mechanistic insights into B cell lymphomagenesis are advancing cancer research.
  • Targeted therapies based on pathogenic principles offer a promising future for treating B cell lymphomas.
  • Understanding the hijacking of normal B cell processes is crucial for effective therapeutic strategies.