Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving Blood Pressure and Weight in Patients with Diabetes.

Journal of National Black Nurses' Association : JNBNA·2018
Same author

Implementing a Pediatric Fall Prevention Policy and Program.

Pediatric nursing·2018
Same author

Appointment Reminders to Decrease 30-Day Readmission Rates to Inpatient Psychiatric Hospitals.

Professional case management·2018
Same author

Increasing physical activity for veterans in the Mental Health Intensive Case Management Program: A community-based intervention.

Perspectives in psychiatric care·2017
Same author

Reflections on Mentoring.

Journal of gerontological nursing·2017
Same author

Diagnosis and management of pityriasis rosea.

The Nurse practitioner·2016

Related Experiment Video

Updated: May 26, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Crushing or splitting medications: unrecognized hazards.

Donna Gill1, Margaret Spain, Barbara J Edlund

  • 1University of South Carolina, Charleston, SC, USA. dgill@musc.edu

Journal of Gerontological Nursing
|January 10, 2012
PubMed
Summary

Older adults may split pills to save money, but this can be dangerous if medications like extended-release tablets are altered. Always consult a healthcare provider before splitting or crushing any medication.

More Related Videos

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Manual Restraint and Common Compound Administration Routes in Mice and Rats
14:10

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Related Experiment Videos

Last Updated: May 26, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Manual Restraint and Common Compound Administration Routes in Mice and Rats
14:10

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Patient Safety

Background:

  • High medication costs impact older adults.
  • Older adults may seek cost-saving measures like pill splitting.
  • Difficulty swallowing pills is common in older populations.

Purpose of the Study:

  • To highlight the risks associated with altering oral medications in older adults.
  • To inform healthcare providers about safe medication administration practices for seniors.
  • To caution patients against unsupervised medication modification.

Main Methods:

  • Review of medication administration guidelines for older adults.
  • Analysis of potential adverse events from splitting or crushing medications.
  • Emphasis on clinical communication regarding medication regimens.

Main Results:

  • Not all oral medications are safe to split or crush.
  • Altering extended-release formulations can lead to dangerous outcomes.
  • Crushing certain medications can compromise efficacy or cause harm.

Conclusions:

  • Healthcare providers must discuss medication administration with older adults.
  • Clear instructions on dosing, splitting, crushing, and route are essential.
  • Patients must be advised to consult professionals before modifying medications.