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Relationship of glucocorticoid dosage to serum bone Gla-protein concentration in patients with rheumatologic
M A Kotowicz1, S Hall, G G Hunder
1Division of Endocrinology, Metabolism, Mayo Clinic, Rochester, Minnesota 55905.
Arthritis and Rheumatism
|October 1, 1990
Abstract:
Serum bone Gla-protein (BGP) measurements in 50 rheumatic disease patients receiving long-term prednisone therapy revealed an inverse relationship (r = -0.71, P less than 0.001) between serum BGP levels and prednisone dosage. Multiple regression analysis demonstrated significant relationships (R2 = 0.72, P less than 0.001) between serum BGP1/2 and prednisone dosage, dosage2, serum creatinine, age, and an age-creatinine interaction. This model predicts the suppression of serum BGP with low dosages of steroids and 50% suppression with dosages of 20-25 mg/day.