Related Experiment Videos
D-penicillamine-induced lupus erythematosus
R J Enzenauer1, S G West, R L Rubin
1Rheumatology Service, Fitzsimons Army Medical Center, Aurora, Colorado 80045.
Arthritis and Rheumatism
|October 1, 1990
Abstract:
We describe a patient who presented with polyarthritis, pleurisy, rash, and a positive antinuclear antibody result after 5 years of D-penicillamine therapy. D-penicillamine-induced antinuclear antibodies were mainly high-titer IgG directed against the (H2A-H2B)-DNA complex. Weak IgM activity with H1 and H2B was also observed. Withdrawal of D-penicillamine therapy resulted in improvement in clinical symptoms and gradual resolution of serologic abnormalities.