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Updated: May 26, 2026
11:02
Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Tooth bioengineering leads the next generation of dentistry
Ying Wang1, Brian Preston, Guoqiang Guan
1Department of Orthodontics, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA.
International Journal of Paediatric Dentistry
|January 10, 2012
Summary
Tooth regeneration using bioengineered tooth germ is advancing rapidly. This review covers recent progress in tooth bioengineering, developmental signaling, and dental stem cells for future dental therapies.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Dental Science
Background:
- Tissue engineering advancements enable tooth regeneration from bioengineered tooth germs in animal models.
- Progress in tooth development mechanisms and dental stem cell research drives tooth regeneration.
- Significant strides have been made in the field of dental tissue regeneration.
Purpose of the Study:
- Review recent advances in tooth bioengineering technology.
- Examine signaling pathways critical to tooth development.
- Discuss dental stem cell biology in the context of tooth regeneration.
Main Methods:
- Literature review of recent developments in tooth bioengineering.
- Analysis of signaling pathways involved in odontogenesis.
- Synthesis of current knowledge on dental stem cells and their role in regeneration.
Main Results:
- Successful regeneration of functional teeth from bioengineered tooth germs in preclinical studies.
- Identification of key signaling pathways regulating tooth development.
- Characterization of dental stem cells with regenerative potential.
Conclusions:
- Understanding these advancements prepares clinicians for revolutionary tooth regeneration therapies.
- Tooth bioengineering is poised to lead the next generation of dental treatments.
- Future clinical trials will involve these novel regenerative approaches.
Related Concept Videos
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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
01:21Tooth Anatomy
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The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.