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Phenotyping drug disposition in oncology

Frans L Opdam1, Hans Gelderblom, Henk-Jan Guchelaar

  • 1Department of Clinical Pharmacy, University Medical Center, Leiden, The Netherlands. f.l.opdam@lumc.nl

Cancer Treatment Reviews
|January 10, 2012
PubMed
Summary

Patient variability in anticancer drug response stems from differences in drug disposition. Phenotyping drug metabolizing enzymes and transporters using in vivo probes can help individualize cancer therapy.

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