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Phenotyping drug disposition in oncology

Frans L Opdam1, Hans Gelderblom, Henk-Jan Guchelaar

  • 1Department of Clinical Pharmacy, University Medical Center, Leiden, The Netherlands. f.l.opdam@lumc.nl

Cancer Treatment Reviews
|January 10, 2012
PubMed

Insights

Patient variability in anticancer drug response stems from differences in drug disposition. Phenotyping drug metabolizing enzymes and transporters using in vivo probes can help individualize cancer therapy.

Area of Science:

  • Pharmacogenomics
  • Oncology
  • Drug Metabolism

Background:

  • Anticancer agent efficacy and toxicity vary significantly among patients.
  • Individual differences in drug disposition, influenced by genetics, physiology, and environment, are key factors in this variability.
  • Personalized medicine approaches are needed to optimize cancer treatment outcomes.

Purpose of the Study:

  • To review the drug disposition of anticancer agents.
  • To explore the utility of phenotyping probes for drug metabolizing enzymes and transporters in oncology.
  • To highlight the potential for individualizing cancer drug therapy.

Main Methods:

  • Literature review of studies on anticancer drug disposition.
  • Analysis of phenotyping probe methodologies for drug metabolizing enzymes (Phase I and II).
  • Evaluation of phenotyping approaches for drug transporters relevant to oncology.

Main Results:

  • Drug disposition significantly impacts anticancer agent efficacy and toxicity.
  • Phenotyping provides a functional assessment of drug metabolizing enzymes and transporters.
  • In vivo phenotyping offers a promising strategy for tailoring drug regimens.

Conclusions:

  • Understanding individual drug disposition is crucial for optimizing anticancer therapy.
  • Phenotyping drug metabolizing enzymes and transporters can guide personalized treatment strategies.
  • In vivo probe-based phenotyping holds potential for improving patient outcomes in oncology.

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